GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2275426 | 1 | rs6675946 | chr1:46371774 | CCDC163P | chr1:45960581-45965646:- | -0.36 | -6.79 | 4.3E-11 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs6677007 | chr1:46400590 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.43 | 3.87E-10 | Body mass index |
| BLCA | cis | rs9371538 | 1 | rs66775662 | chr6:151876216 | C6orf97 | chr6:151815175-151942327:+ | 0.27 | 3.99 | 7.84E-5 | Bone mineral density (spine) |
| BLCA | cis | rs17030613 | 1 | rs6679 | chr1:113243048 | ST7L | chr1:113066142-113162405:- | 0.43 | 6.19 | 1.55E-9 | Diastolic blood pressure;Blood pressure |
| BLCA | cis | rs2275426 | 1 | rs6680380 | chr1:46300189 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.18E-11 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs6695809 | chr1:46285461 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -6.99 | 1.19E-11 | Body mass index |
| BLCA | cis | rs6684514 | 1 | rs66965793 | chr1:156285814 | BGLAP | chr1:156182784-156213112:+ | 0.23 | 3.91 | 0.000109 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BLCA | cis | rs2275426 | 1 | rs6700597 | chr1:46284246 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -6.99 | 1.19E-11 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs6701614 | chr1:46309420 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.18E-11 | Body mass index |
| BLCA | cis | rs9309473 | 1 | rs6705489 | chr2:73648811 | ALMS1P | chr2:73872046-73912692:+ | 0.34 | 4.93 | 1.24E-6 | Metabolite levels |
| BLCA | cis | rs6547741 | 1 | rs6706610 | chr2:27778091 | C2orf16 | chr2:27799389-27805588:+ | 0.22 | 3.83 | 0.000152 | Oral cavity cancer |
| BLCA | cis | rs67073037 | 1 | rs67073037 | chr2:29119585 | TRMT61B | chr2:29072690-29093175:- | 0.33 | 5.04 | 7.05E-7 | Breast cancer (estrogen-receptor negative);Breast cancer |
| BLCA | cis | rs9309473 | 1 | rs6707722 | chr2:73654363 | ALMS1P | chr2:73872046-73912692:+ | 0.38 | 5.71 | 2.23E-8 | Metabolite levels |
| BLCA | cis | rs4372836 | 1 | rs6707848 | chr2:28988083 | TRMT61B | chr2:29072690-29093175:- | -0.33 | -5.77 | 1.66E-8 | Body mass index |
| BLCA | cis | rs2288073 | 1 | rs6708328 | chr2:24412413 | LOC375190 | chr2:24299728-24397519:+ | -0.24 | -4.07 | 5.63E-5 | Venous thromboembolism (SNP x SNP interaction) |